Tadalista 5 mg contains tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, which works by relaxing the blood vessels in the penis to improve blood flow and support erections. Despite its effectiveness, the medication has a limited duration of action due to the body’s metabolism and elimination processes. Once ingested, tadalafil is absorbed into the bloodstream and gradually broken down by the liver enzyme CYP3A4. Over time, the concentration of the drug decreases, reducing its effectiveness. Typically, Tadalista 5 maintains its effects for up to 24 hours, which is why it is not active indefinitely. Factors such as age, liver function, kidney function, and overall health can further influence how long the drug remains effective. The limited duration helps minimize the risk of prolonged side effects while allowing patients to plan sexual activity within a predictable time frame.