Malegra 100 contains sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It is generally not recommended to take Malegra 100 mg together with other ED medications, especially those also containing PDE5 inhibitors such as tadalafil (Cialis), vardenafil (Levitra), or avanafil (Stendra). Combining these drugs can lead to an excessive drop in blood pressure, increasing the risk of serious side effects like dizziness, fainting, heart attack, or stroke.

Additionally, taking multiple ED drugs simultaneously can increase the likelihood of adverse effects like headaches, flushing, nasal congestion, and visual disturbances. If a patient feels that one medication is ineffective, they should consult a healthcare provider before switching or combining treatments. The doctor may recommend a safer alternative or adjust the dosage rather than combining different ED drugs. Safety and proper medical guidance are essential when managing erectile dysfunction therapy.