Malegra FXT Plus is a pharmaceutical formulation that combines two active ingredients—Sildenafil Citrate (100 mg) and Fluoxetine (60 mg)—to address two prevalent male sexual health concerns: erectile dysfunction (ED) and premature ejaculation (PE). Malegra FXT Plus functions as a phosphodiesterase type 5 (PDE5) inhibitor. During sexual arousal, it enhances blood flow to the penis by inhibiting the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels relax the smooth muscles and dilate blood vessels in the penile region, facilitating a firm and sustained erection .

Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), primarily modulates serotonin levels in the brain. By delaying the reuptake of serotonin, it prolongs its action, which can help in delaying ejaculation. This mechanism not only aids in controlling the timing of ejaculation but also contributes to improved mood and reduced performance anxiety, enhancing overall sexual satisfaction .