Patients often have unclear symptoms. The symptoms will depend on the severity of the disease at different levels. The most common symptoms are swelling and feeling tight on the hand bones in the affected area. In some patients, the doctor may come to see the fracture caused by the disease causing the strength of the bones to decrease. In the period that the disease progresses for a period of time May have a pus flowing out to be seen on the skin In addition to other symptoms such as fever, loss of appetite, weight loss, which is not usually found in the case of a disease in one location But may be found in cases of multiple lesions>> slotxo